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Index > Protein center > ATP5B(Gene name) > Bovine
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  • ATP5B (Gene name),
  • ATP synthase subunit beta, mitochondrial (Protein name ),  ATPB_BOVIN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    ATP5B;
    Protein name:
    ATP synthase subunit beta, mitochondrial;
    Alternative:

    Organism:
    Bovine (Bos taurus). 
    General Annotation
    Sub Unit:
    F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
    Function:
    Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Subunits alpha and beta form the catalytic core in F(1). Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits.
    Subcellular Location:
    Mitochondrion Mitochondrion inner membrane Peripheral membrane protein.
    Protein Attributes:
    Sequence length:
    528
    Sequence:
    50:
    MLGLVGRVVA | ASASGALRGL | SPSAPLPQAQ | LLLRAAPAAL | QPARDYAAQA | 
    100:
    SPSPKAGATT | GRIVAVIGAV | VDVQFDEGLP | PILNALEVQG | RETRLVLEVA | 
    150:
    QHLGESTVRT | IAMDGTEGLV | RGQKVLDSGA | PIRIPVGPET | LGRIMNVIGE | 
    200:
    PIDERGPIKT | KQFAAIHAEA | PEFVEMSVEQ | EILVTGIKVV | DLLAPYAKGG | 
    250:
    KIGLFGGAGV | GKTVLIMELI | NNVAKAHGGY | SVFAGVGERT | REGNDLYHEM | 
    300:
    IESGVINLKD | ATSKVALVYG | QMNEPPGARA | RVALTGLTVA | EYFRDQEGQD | 
    350:
    VLLFIDNIFR | FTQAGSEVSA | LLGRIPSAVG | YQPTLATDMG | TMQERITTTK | 
    400:
    KGSITSVQAI | YVPADDLTDP | APATTFAHLD | ATTVLSRAIA | ELGIYPAVDP | 
    450:
    LDSTSRIMDP | NIVGSEHYDV | ARGVQKILQD | YKSLQDIIAI | LGMDELSEED | 
    500:
    KLTVSRARKI | QRFLSQPFQV | AEVFTGHLGK | LVPLKETIKG | FQQILAGEYD | 
    528:
    HLPEQAFYMV | GPIEEAVAKA | DKLAEEHS
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
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    Related Databases
    String:
    UniGene:
    SMR:
    Pfam:
    Uniprot:
     
    FOR
    ELISA Kit for Bovine ATP synthase subunit beta, mitochondrial
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    E12585r
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    ELISA Kit for Bovine ATP synthase subunit beta, mitochondrial
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    E12585d
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    ELISA Kit for Bovine ATP synthase subunit beta, mitochondrial
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    E12585m
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    ELISA Kit for Bovine ATP synthase subunit beta, mitochondrial
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    E12585h
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    ELISA Kit for Bovine ATP synthase subunit beta, mitochondrial
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    E12585c
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    ELISA Kit for Bovine ATP synthase subunit beta, mitochondrial
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    E12585b
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    96T
    CLIA Kit for Bovine ATP synthase subunit beta, mitochondrial
    Cat.:
    U12585m
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    96T
    CLIA Kit for Bovine ATP synthase subunit beta, mitochondrial
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    U12585c
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    96T
    CLIA Kit for Bovine ATP synthase subunit beta, mitochondrial
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    U12585b
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    CLIA Kit for Bovine ATP synthase subunit beta, mitochondrial
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    U12585d
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    96T
    CLIA Kit for Bovine ATP synthase subunit beta, mitochondrial
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    U12585h
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    96T
    CLIA Kit for Bovine ATP synthase subunit beta, mitochondrial
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    U12585r
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    Packing:
    96T
    Polyclonal Antibody for Bovine ATP synthase subunit beta, mitochondrial
    Polyclonal Antibody for Bovine ATP synthase subunit beta, mitochondrial
    Polyclonal Antibody for Bovine ATP synthase subunit beta, mitochondrial
    Polyclonal Antibody for Bovine ATP synthase subunit beta, mitochondrial
    Cat.:
    P12585Rb-m
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Bovine ATP synthase subunit beta, mitochondrial
    Cat.:
    P12585Rb-r
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Bovine ATP synthase subunit beta, mitochondrial
    Cat.:
    P12585Rb-h
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    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Bovine ATP synthase subunit beta, mitochondrial
    Monoclonal Antibody for Bovine ATP synthase subunit beta, mitochondrial
    Monoclonal Antibody for Bovine ATP synthase subunit beta, mitochondrial
    Monoclonal Antibody for Bovine ATP synthase subunit beta, mitochondrial
    Monoclonal Antibody for Bovine ATP synthase subunit beta, mitochondrial
    Monoclonal Antibody for Bovine ATP synthase subunit beta, mitochondrial
    Protein for Bovine ATP synthase subunit beta, mitochondrial
    Protein for Bovine ATP synthase subunit beta, mitochondrial
    Protein for Bovine ATP synthase subunit beta, mitochondrial
    Protein for Bovine ATP synthase subunit beta, mitochondrial
    Protein for Bovine ATP synthase subunit beta, mitochondrial
    Protein for Bovine ATP synthase subunit beta, mitochondrial

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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Isolation and characterization of a complementary DNA for the nuclear-coded precursor of the beta-subunit of bovine mitochondrial F1-ATPase."
      Breen G.A.M. , Holmans P.L. , Garnett K.E.
      Biochemistry27:3955-3961(1988) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
    2. 2.
      NIH - Mammalian Gene Collection (MGC) project
      Submitted (2006-05) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      strain: Hereford.
      tissue: Ascending colon.
    3. 3.
      "The amino acid sequence of the beta-subunit of ATP synthase from bovine heart mitochondria."
      Runswick M.J. , Walker J.E.
      J. Biol. Chem.258:3081-3089(1983) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 51-528
    4. 4.
      "Primary structure and subunit stoichiometry of F1-ATPase from bovine mitochondria."
      Walker J.E. , Fearnley I.M. , Gay N.J. , Gibson B.W. , Northrop F.D. , Powell S.J. , Runswick M.J. , Saraste M. , Tybulewicz V.L.J.
      J. Mol. Biol.184:677-701(1985) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 49-528
    5. 5.
      "Sequence analysis of cDNAs for the human and bovine ATP synthase beta subunit: mitochondrial DNA genes sustain seventeen times more mutations."
      Wallace D.C. , Ye J. , Neckelmann S.N. , Singh G. , Webster K.A. , Greenberg B.D.
      Curr. Genet.12:81-90(1987) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 172-528
      tissue: Heart.
    6. 6.
      "Identification of the subunits of F1F0-ATPase from bovine heart mitochondria."
      Walker J.E. , Lutter R. , Dupuis A. , Runswick M.J.
      Biochemistry30:5369-5378(1991) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 47-55
      tissue: Heart.
    7. 7.
      "When beef-heart mitochondrial F1-ATPase is inhibited by inhibitor protein a nucleotide is trapped in one of the catalytic sites."
      Milgrom Y.M.
      Eur. J. Biochem.200:789-795(1991) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 388-422
      tissue: Heart.
    8. 8.
      "The sites of labeling of the beta-subunit of bovine mitochondrial F1-ATPase with 8-azido-ATP."
      Hollemans M. , Runswick M.J. , Fearnley I.M. , Walker J.E.
      J. Biol. Chem.258:9307-9313(1983) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ATP-BINDING SITE
    9. 9.
      "Structural elucidation of N-terminal post-translational modifications by mass spectrometry: application to chicken enolase and the alpha- and beta-subunits of bovine mitochondrial F1-ATPase."
      Gibson B.W. , Daley D.J. , Williams D.H.
      Anal. Biochem.169:217-226(1988) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF N-TERMINUS
    10. 10.
      "Association of two proteolipids of unknown function with ATP synthase from bovine heart mitochondria."
      Chen R. , Runswick M.J. , Carroll J. , Fearnley I.M. , Walker J.E.
      FEBS Lett.581:3145-3148(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION IN THE ATP SYNTHASE COMPLEX
    11. 11.
      "Cyclophilin D modulates mitochondrial F0F1-ATP synthase by interacting with the lateral stalk of the complex."
      Giorgio V. , Bisetto E. , Soriano M.E. , Dabbeni-Sala F. , Basso E. , Petronilli V. , Forte M.A. , Bernardi P. , Lippe G.
      J. Biol. Chem.284:33982-33988(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PPIF
    12. 12.
      "Structure at 2.8-A resolution of F1-ATPase from bovine heart mitochondria."
      Abrahams J.P. , Leslie A.G.W. , Lutter R. , Walker J.E.
      Nature370:621-628(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF 48-528
    13. 13.
      "The structure of bovine F1-ATPase complexed with the peptide antibiotic efrapeptin."
      Abrahams J.P. , Buchanan S.K. , van Raaij M.J. , Fearnley I.M. , Leslie A.G. , Walker J.E.
      Proc. Natl. Acad. Sci. U.S.A.93:9420-9424(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (3.1 ANGSTROMS) OF 48-528
    14. 14.
      "Bovine F1-ATPase covalently inhibited with 4-chloro-7-nitrobenzofurazan: the structure provides further support for a rotary catalytic mechanism."
      Orriss G.L. , Leslie A.G. , Braig K. , Walker J.E.
      Structure6:831-837(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS) OF 48-528
    15. 15.
      "The structure of bovine F1-ATPase in complex with its regulatory protein IF1."
      Cabezon E. , Montgomery M.G. , Leslie A.G. , Walker J.E.
      Nat. Struct. Biol.10:744-750(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF 47-528 IN COMPLEX WITH ATPIF1; ATP5A1 AND ATP5C1
    16. 16.
      "How the regulatory protein, IF(1), inhibits F(1)-ATPase from bovine mitochondria."
      Gledhill J.R. , Montgomery M.G. , Leslie A.G. , Walker J.E.
      Proc. Natl. Acad. Sci. U.S.A.104:15671-15676(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS) OF 47-528 IN COMPLEX WITH ATPIF1; ATP5A1; ATP5C1; ATP5D AND ATP5E
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